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KMID : 0371420221020040193
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Annals of Surgical Treatment and Research
2022 Volume.102 No. 4 p.193 ~ p.204
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Impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis
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Hong Suk-Kyun
Lee Kwang-Woong
Lee Sola
Hong Su-Young
Suh Sang-Gyun
Han Eui-Soo
Choi Young-Rok
Yi Nam-Joon
Suh Kyung-Suk
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Abstract
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Purpose: The aim of this study was to compare surgical outcomes after liver resection for hepatocellular carcinoma (HCC) according to tumor size using a large, nationwide cancer registry-based cohort and propensity score matching.
Methods: From 2008 to 2015, a total of 12,139 patients were diagnosed with liver cancer and registered in the Korean Primary Liver Cancer Registry. Patients without distant metastasis who underwent hepatectomy as a primary treatment were selected. We performed 1:1 propensity score matching between the small (<5 cm), large (≥5 cm and <10 cm), and huge (≥10 cm) groups.
Results: Overall, 265 patients in the small and large groups were compared, and 64 patients each in the large and huge groups were compared. The overall and progression-free survival rates were significantly lower in the large group than in the small group (P < 0.001 and P < 0.001, respectively). Overall survival tended to be poorer in the huge group than in the large group (P = 0.051). The progression-free survival rate was significantly lower in the huge group than in the large group (P = 0.002).
Conclusion: Although primary liver resection can be considered even in patients with huge HCC, greater caution with careful screening for recurrence is needed.
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KEYWORD
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Disease progression, Hepatectomy, Hepatocellular carcinoma, Survival
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